Light-Sheet Microscopy System, Lightsheet 7, ZEISS

Light Sheet Imaging System ZEISS Lightsheet 7

ZEISS Lightsheet 7 is a light sheet fluorescence imaging system designed for multiview imaging of living and optically cleared specimens.

The system combines fast volumetric acquisition with gentle plane illumination, enabling long-term observation of biological processes while preserving sample integrity.

With its flexible configuration and stable enclosed architecture, Lightsheet 7 supports a wide range of applications — from live-cell imaging to large cleared tissue and whole-organism studies.

Key Features

• Multiview imaging for complete 3D reconstruction of complex samples.
• Long-term imaging of living specimens with reduced phototoxicity.
• Imaging of large cleared samples up to 2 cm in size.
• Broad refractive index compatibility (1.33 – 1.58).
• High stability and reproducibility in long experiments.

Technologies

• Light sheet fluorescence system (LSFM): fast optical sectioning with minimal light exposure.
• Multiview imaging: improved image quality and reconstruction accuracy.
• Pivot Scan: artifact-free imaging with enhanced quality.
• Smart software tools: automated control and data processing.

Applications

• Imaging of optically cleared tissues and organs.
• Developmental biology and whole-organism studies.
• Long-term live imaging of cells and model organisms.
• Organoids, spheroids, and large biological samples.
• 3D visualization of complex biological systems.

Advantages

• System flexibility: adapts to different sample types and clearing methods.
• Large sample capability: imaging of millimeter-scale specimens.
• Gentle plane illumination: minimal photodamage for long-term imaging.
• High speed: fast volumetric acquisition using camera-based detection.
• Ease of use: turnkey system with automated workflows.

ZEISS Lightsheet 7 is a versatile imaging system for both living and cleared samples, delivering reliable 3D visualization across a wide range of biological applications.